卢宇靖 教授

作者: 时间:2019-01-12 点击数:

姓名:卢宇靖

职称:教授

所属学院:生物医药学院

导师类别:博士生导师、硕士生导师

职务:副院长、副主任

科研方向:药物化学,核酸化学生物学,药食同源,酶催化合成。

联系方式:luyj@gdut.edu.cn,28069399@qq.com

硕士博士招生学院:生物医药学院


个人简介:卢宇靖博士,广东工业大学生物医药学院副院长、教授、博士生导师,任职广东工业大学智慧医疗技术创新中心副主任,广东省药食同源综合利用与研究开发工程中心核心成员。入选广东省科技特派员、广东省青联委员、广东省高等学校“千百十工程”培养对象和广工大“培英育才”计划。曾获广东省科学技术奖一等奖、教育部自然科学奖二等奖、广东省轻工业协会科技进步一等奖、叶剑英基金科学技术进步奖三等奖。近年致力于重要特殊核酸G-四链体的结构与功能、抗癌药物、生物探针及检测诊断仪器相关研究工作;也开展特色药食同源资源,如柑橘(柚、陈皮、化橘红)的综合利用和产业化。在Nucleic Acid Res、J Med Chem、Biosensors & Bioelectronics、Chem Eng J等专业学术刊物上发表SCI论文近50篇;SCI论文总被引用次数超过2300次,单篇引用超过400次;申请专利43项,授权15项;主持国家自然科学基金(两项)、广东省自然科学基(两项)、广州市产学研协调创新重大专项、广东省农业科技创新项目;技术成果转化获广东省高新技术产品3项。


教育背景:

2008年6月-2010年6月,香港理工大学,应用生物与化学技术系、手性科学国家重点实验室,博士后,合作导师:黄国贤教授 副校长 国重室主任

2003年9月-2008年6月,中山大学,药学院药物化学专业,硕博连读,获博士学位

1999年9月-2003年6月,中山大学,化工学院应用化学专业,获学士学位


工作经历:

2019年-今,广东工业大学生物医药学院,教授,博士生导师,副院长

2016年-2018年,广东工业大学轻工化工学院,教授,硕士生导师

2011年-2016年,广东工业大学轻工化工学院,副教授,硕士生导师

2010年-2011年,广东工业大学轻工化工学院,讲师


学术兼职:

广东省药学会制药工程专业委员会委员、药食两用资源专题组副组长

广东省药学会药物化学专业委员会委员

广东省农业科技特派员

广东省科技特派员

国家自然科学基金青年基金、地区基金、面上基金评审专家


主要荣誉:

2018年,广东省青联委员

2016年,广东省优秀学生(研究生)指导老师

2013年,广东省轻工业协会科技进步奖一等奖

2012年,第七批广东省“千百十”校级培养对象

2011年,广东省科学技术奖励一等奖

2011年,广东工业大学“培英育才”(科研类)培养对象


代表性论文:

[1] W. Long, B.-X. Zheng, Y. Li, X.-H. Huang, D.-M. Lin, C.-C. Chen, J.-Q. Hou, T.-M. Ou, W.-L. Wong*, K. Zhang*, Yu-Jing Lu(卢宇靖)*, “Rational design of small-molecules to recognize G-quadruplexes of c-MYC promoter and telomere and the evaluation of their in vivo antitumor activity against breast cancer,”Nucleic Acids Research, 2022, 50(4): 1829-1848.(IF19.16,ESI高被引论文)

[2] Yi-Han Zhang, Xuan-He Huang, Wing-Leung Wong*, Jun-Ren Luo, Xiao-Chun Guo, Wenjie Liu, Jinqiang Hou, Meng-Ting She, Wen-Hao Jiang, Ning Sun*,Yu-Jing Lu*. A red fluorescent small-molecule for visualization of higher-order cyclic dimeric guanosine monophosphate (c-di-GMP) structure in live bacterial cells and real-time monitoring of biofilm formation on biotic and abiotic surfaces.Sensors and Actuators B-Chemical, 2023, 376, 132992.(IF9.221, SCI 1区)

[3] Yongyu Xu, Zebin Huang, Guangping Wu, Fujun Jin, Shuojia Lin, Chuang Zhang, Jie Zheng, Wenjie Liu, Jinqiang Hou,Yu-Jing Lu*. Bioinformatic assay reveal the potential mechanism of Guizhi-Shaoyao-Zhimu decoction against rheumatoid arthritis and mild-to-moderate COVID-19.Computer Methods and Programs in Biomedicine, 2023, 238, 107584. (IF7.027, SCI1区)

[4] Meng-Ting She, Jia-Wei Yang, Bo-Xin Zheng, Wei Long, Xuan-He Huang, Jun-Ren Luo, Ze-Xin Chen, Ao-Lu Liu, Dong-Peng Cai, Wing-Leung Wong*,Yu-Jing Lu*. Design mitochondria-specific fluorescent turn-on probes targeting G-quadruplexes for live cell imaging and mitophagy monitoring study.Chemical Engineering Journal, 2022, 446, 136947. IF 16.744(IF16.744 , SCI 1区)

[5] Dong-Xiao Zhong, Meng-Ting She, Xiao-Chun Guo, Bo-Xin Zheng, Xuan-He Huang, Yi-Han Zhang, Hooi-Leng Ser, Wing-Leung Wong*, Ning Sun*,Yu-Jing Lu*. Design and synthesis of quinolinium-based derivatives targeting FtsZ for antibacterial evaluation and mechanistic study.European Journal of Medicinal Chemistry, 2022, 236, 114360.(IF7.088, SCI 1区)

[6] Bo-Xin Zheng, Wei Long, Meng-Ting She, Yakun Wang, Dong Zhao, Jie Yu, Alan Siu-Lun Leung, Ka Hin Chan, Jinqiang Hou,Yu-Jing Lu*, Wing-Leung Wong*. A Cytoplasm-Specific Fluorescent Ligand for Selective Imaging of RNA G-Quadruplexes in Live Cancer Cells.Chemistry-A European Journal, 2023. https://doi.org/10.1002/chem.202300705(IF5.02, SCI 1区)

[7] Xuan-He Huang, Meng-Ting She, Yi-Hang Zhang, Yi-Fu Liu, Dong-Xiao Zhong, Yi-Han Zhang, Jun-Xia Zheng, Ning Sun*, Wing-Leung Wong*,Yu-Jing Lu*. Novel quinoline-based derivatives as the PqsR inhibitor against Pseudomonas aeruginosa PAO1.Journal of Applied Microbiology, 2022, 133, 2167-2181.(IF4.059, SCI 2区)

[8] Wei Long, Bo-Xin Zheng, Xuan-He Huang, Meng-Ting She, Ao-Lu Liu, Kun Zhang*, Wing-Leung Wong* andYu-Jing Lu*. Molecular Recognition and Imaging of Human Telomeric G‑Quadruplex DNA in Live Cells: A Systematic Advancement of Thiazole Orange Scaffold To Enhance Binding Specificity and Inhibition of Gene Expression.Journal of Medicinal Chemistry, 2021, 64: 2125−2138.(IF 8.039,SCI 1区)

[9] Bo-Xin Zheng, Meng-Ting She, Wei Long a , Yong-Yu Xu a , Yi-Han Zhang a , Xuan-He Huang, Wenjie Liu, Jin-Qiang Hou, Wing-Leung Wong* andYu-Jing Lu*. A small-sized benzothiazole–indolium fluorescent probe: the study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging.Chemical Communications, 2020, 56.(IF6.065, SCI 2区)

[10] Bo-Xin Zheng, Wei Long, Yi-Han Zhang, Xuan-He Huang, Cui-Cui Chen, Dong-Xiao Zhong, Meng-Ting She, Ze-Xin Chen, Dong-Peng Cai,Yu-Jing Lu*, Wing-Leung Wong*. Rational design of Red fluorescent and selective G-quadruplex DNA sensing probes: The study of interaction signaling and the molecular structural relationship achieving high specificity.Sensors and Actuators B: Chemical, 2020, 314, 128075.. IF 9.221(SCI 1区)

[11] Senyuan Cai, Wenchang Yuan, Ying Li, Xuanhe Huang, Qi Guo, Ziwei Tang, Zhiyuan Fang, Hai Lin, Wing-Leung Wong, Kwok-Yin Wong,Yu-Jing Lu, Ning Sun*. Antibacterial activity of indolyl-quinolinium derivatives and study their mode of action.Bioorganic &Medicinal Chemistry, 2019, 27, 1274-1282.(IF 3.461, SCI 2区)

[12] Xianwei Li*, Tianzhang Wang,Yu-Jing Lu*, Shaomin Ji, Yanping Huo, Bifu Liu*. Copper-catalyzed oxidative multicomponent reaction: synthesis of imidazo fused heterocycles with molecular oxygen.Org. Biomol. Chem., 2018, 16, 7143–7151.(IF 3.890, SCI 1区)

[13] Yuan-Yuan Zheng, Ruo-Lan Du, Sen-Yuan Cai, Zhi-Hua Liu, Zhi-Yuan Fang, Ting Liu, Lok-Yan So,Yu-Jing Lu*, Ning Sun and Kwok-Yin Wong. Study of Benzofuroquinolinium Derivatives as a New Class of Potent Antibacterial Agent and the Mode of Inhibition Targeting FtsZ.Frontiers in Microbiology, 2018, 9, 1937.(IF 6.064, SCI 1区)

[14] Wei Long,Yu-Jing Lu*, Kun Zhang, Xuan-He Huang, Jin-Qiang Hou, Sen-Yuan Cai, Ying Li, Xian Du, Leonard G. Luyt, Wing-Leung Wong, Cheuk-Fai Chow. Boosting the turn-on fluorescent signaling ability of thiazole orange dyes: The effectiveness of structural modification site and its unusual interaction behavior with nucleic acids.Dyes and Pigments, 159 (2018) 449–456.(IF 5.122, SCI 1区)

[15] Cong Wang,Yu-Jing Lu, Sen-Yuan Cai, Wei Long, Yuan-Yuan Zheng, Jing-Wen Lin, Yan Yan, Xuan-He Huang, Wing-Leung Wong, Kun Zhang, Cheuk-Fai Chow. Advancing small ligands targeting RNA for better binding affinity and specificity: A study of structural influence through molecular design approach.Sensors and Actuators B: Chemical, 262, 2018, 386-394.(IF 9.221, SCI 1区)

[16] Sun N, Du RL, Zheng YY, Huang BH, Guo Q, Zhang RF, Wong KY,Lu Yu-Jing*. Antibacterial activity of N-methylbenzofuro[3,2-b]quinoline and N-methylbenzoindolo[3,2-b]-quinoline derivatives and study of their mode of action.European Journal of MedicinalChemistry. 135, 2017, 1-11.(IF 7.088, SCI 1区)

[17] Ning Sun,Yu-Jing Lu*, Fung-Yi Chan, Ruo-Lan Du, Yuan-yuan Zheng, Kun Zhang, Lok-Yan So, Ruben Abagyan, Chao Zhuo, Yun-Chung Leung and Kwok-Yin Wong* . A thiazole 0range derivative targeting the bacterial protein FtsZ shows potent antibacterial activity.Frontiers in Microbiology, 2017, 8, 855.(IF 6.064, 被引14次, SCI 1区)

[18]Yu-Jing Lu*, Xiao-Lu Guo, Miao-Han Xu, Wei-Wu Chen, Cheuk-Fai Chow. Selective visualization of DNA G-quadruplex structures in live cells with 1-methylquinolinium-based molecular probes: The importance of indolyl moiety position towards specificity.Dyes andPigments, 143, 2017, 331-341. IF 5.122(SCI 1区)

[19] Ning Sun, Cong Wang, Miao-Han Xu,Yu-Jing Lu*, Yuan-Yuan Zheng, Yan Yan, Xiao-Lu Guo, Jinqiang Hou, Kun Zhang, Leonard G. Luyt, Wing-Leung Wong∗, Cheuk-Fai Chow. The interaction of a structural flexible small molecule with nucleic acid structures: Investigation of the origin of fluorescence signal discrimination in sensing and the utilization in live cell imaging.Sensors and Actuators B: Chemical, 250, 2017, 543-551. IF 9.221(SCI 1区)

[20]Yu-Jing Lu*, Dong-Ping Hu, Kun Zhang, Wing-Leung Wong, Cheuk-Fai Chow. New pyridinium-based fluorescent dyes: A comparison of symmetry and side-group effects on G- Quadruplex DNA binding selectivity and application in live cell imaging.Biosensors andBioelectronics, 2016, 81, 373-381. IF 12.545(SCI 1区)

[21]Yu-Jing Lu*, Qiang Deng, Jin-Qiang Hou, Dong-Ping Hu, Zheng-Ya Wang, Kun Zhang, Leonard G. Luyt, Wing-Leung Wong, and Cheuk-Fai Chow. Molecular Engineering of Thiazole Orange Dye: Change of Fluorescent Signaling from Universal to Specific upon Binding with Nucleic Acids in Bioassay.ACS Chemical Biology, 2016, 11, 1019-1029. IF 4.634(SCI 2区)

[22]Yu-Jing Lu*, Qiang Deng, Dong-Ping Hu, Zheng-Ya Wang, Bao-Hua Huang, Zhi-Yun Du, Yan-Xiong Fang, Wing-Leung Wong, Kun Zhang and Cheuk-Fai Chow, A molecular fluorescent dye for specific staining and imaging of RNA in live cells: a novel ligand integration from classical thiazole orange and styryl compounds.ChemicalCommunications, 2015, 51, 15241-15244. IF6.290(SCI 2区)

[23]Yu-Jing Lu*, Dong-Ping Hu, Qiang Deng, Zheng-Ya Wang, Bao-Hua Huang, Yan-Xiong Fang, Kun Zhang and Wing-Leung Wong, Sensitive and selective detection of uracil-DNA glycosylase activity with a new pyridinium luminescent switch-on molecular probe.undefinedyst, 2015,140, 5998-6004. IF 5.227(SCI 1区)

[24]Yu-Jing Lu*, Zheng-Ya Wang, Dong-Ping Hu, Qiang Deng, Bao-Hua Huang, Yan-Xiong Fang, Kun Zhang, Wing-Leung Wong, Cheuk-Fai Chow. Benzothiazole-substituted benzofuroquinolinium dyes as new fluorescent probes for G-quadruplex DNA.Dyes andPigments, 2015, 122, 94–102. IF 5.122(SCI 1区)

[25]Yu-Jing Lu, Wing-Leung Wong, Cheuk-Fai Chow, A surfactant-like ionic liquid with permanganate dissolved as a highly selective epoxidation system.Catalysis Communications, 2015, 69, 25-28. IF 3.510(SCI 3区)

[26]Yu-Jing Lu, Na Ma, Yu-jun Li, Zhen-yu Lin, Bin Qiu*, Guo-nan Chen*, Kwok-Yin Wong. Styryl quinolinium/G-quadruplex complex for dual-channel fluorescent sensing of Ag+ and cysteine.Sensors and Actuators B, 2012, 173, 295-299. IF 9.221(SCI 1区)

[27]Yu-Jing Lu, Siu-Cheong Yan, Fung-Yi Chan, Lan Zou, Wai-Hong Chung, Wing-Leung Wong, Bin Qiu, Ning Sun, Pak-Ho Chan, Zhi-Shu Huang, Lian-Quan Gu, and Kwok-Yin Wong. Benzothiazole-substituted benzofuroquinolinium dye: a selective switch-on fluorescent probe for G-quadruplex.Chemical Communication. 2011, 47, 4971-4973. IF 6.065(SCI 2区)

[28]Yu-Jing Lu, Tian-Miao Ou, Jia-Heng Tan, Jin-Qiang Hou, Wei-Yan Shao, Dan Peng, Ning Sun, Xiao-Dong Wang, Wei-Bin Wu, Xian-Zhang Bu, Zhi-Shu Huang, Dik-Lung Ma, Kwok-Yin Wong, Lian-Quan Gu. 5-N-Methylated Quindoline Derivatives as Telomeric G-Quadruplex Stabilizing Ligands: Effects of 5-N Positive Charge on Quadruplex Binding Affinity and Cell Proliferation.Journal of Medicinal Chemistry, 2008, 51, 6381-6392. IF 8.039(SCI 1区)

[29] Tian-Miao Ou, Jing Lin,Yu-Jing Lu, Jin-Qiang Hou, Jia-Heng Tan, Shu-Han Chen, Zeng Li, Yan-Ping Li, Ding Li, Lian-Quan Gu, Zhi-Shu Huang, Inhibition of Cell Proliferation by Quindoline Derivative (SYUIQ-05) through its Preferential Interaction with c-myc Promoter G-Quadruplex,Journal of Medicinal Chemistry, 2011, 54, 5671-5679.IF 8.039,被引83次(SCI 1区)

[30] Tian-Miao Ou#,Yu-Jing Lu#,Chi Zhang, Zhi-Shu Huang, Xiao-Dong Wang, Jia-Heng Tan, Yuan Chen, Dik-Lung Ma, Kwok-Yin Wong, Johnny Cheuk-On Tang, Albert Sun-Chi Chan , Lian-Quan Gu. Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives.Journal of Medicinal Chemistry, 2007, 50, 1465-1474. (Contributed equally with 1st author) IF 8.039(SCI 1区)

[31]Yu-Jing Lu, Ning Sun, Zhi Shu Huang, Lian Quan Gu. A rapid and efficient synthesis of indoloquinolinone and its analogues under microwave irradiation.Chinese Chemical Letters, 2008, 19, 518-520. IF 8.455(SCI 1区)

[32] Tian-Miao Ou,Yu-Jing Lu, Jia-Heng Tan, Zhi-Shu Huang, Kwok-Yin Wong, Lian-Quan Gu. G-quadruplexes: targets in anticancer drug design.ChemMedChem, 2008, 3,690-713. IF 3.540,被引442次(SCI 3区)

[33] Jia-Heng Tan,Yu-Jing Lu, Zhi-Shu Huang, Lian-Quan Gu and Jian-Yong Wu. Spectroscopic studies of DNA binding modes of cation-substituted anthrapyrazoles derived from emodin.European Journal of Medicinal Chemistry, 2007, 42, 1169-1175. IF 7.088,被引52次(SCI 1区)

[34] J-M Zhou, X-F Zhu,Y-J Lu, R Deng, Z-S Huang, Y-P Mei, Y Wang, W-L Huang, Z-C Liu, L-Q Gu and Y-X Zeng. Senescence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines.Oncogene, 2006, 25, 503-511. IF 8.756,被引110 次(SCI 1区)

[35] Jin-Lin Zhou,Yu-Jing Lu, Tian-Miao Ou, Jun-Min Zhou, Zhi-Shu Huang, Xiao-Feng Zhu, Cui-Juan Du, Xian-Zhang Bu, Lin Ma, Lian-Quan Gu, Yue-Ming Li, and Albert Sun-Chi Chan. Synthesis and Evaluation of Quindoline Derivatives as G-Quadruplex Inducing and Stabilizing Ligands and Potential Inhibitors of Telomerase.Journal of Medicinal Chemistry, 2005, 48, 7315-7321. IF 8.039,被引170次(SCI 1区)


部分授权发明专利:

[1] 张艺瀚 卢宇靖 郭晓纯 钟家本 方志远。一种用于检测核酸胞嘧啶脱氨酶APOBEC3B的试剂盒及其应用。-202111480097.7,授权;

[2] 佘梦婷 卢宇靖 郑伯鑫 龙威 洪哲鑫 陈泽鑫 蔡东鹏。一种吲哚类化合物及其制备方法与应用。-202110466598.3,授权;

[3] 许泳瑜 卢宇靖 黄泽彬 钟家本 张创。一种抑制巨噬细胞活化的组合物及其在制备抗炎制品中的应用。-202111052928.0,授权;

[4] 卢宇靖 陈翠翠 郑伯鑫 蔡森源 黄玄贺 李莹 龙威 佘梦婷。苯乙烯喹啉衍生物在制备抗耐药菌药物中的应用和抗耐药菌药物。- 201910759313.8,授权;

[5] 黄玄贺 卢宇靖 蔡森源 李莹 龙威 佘梦婷 林少莹 黄宝华 张焜。一种喹啉芳香乙烯类衍生物及其制备方法和应用。- 201810989477.5,授权;

[6] 卢宇靖 李莹 蔡森源 郑园园 龙威 王聪。吲哚乙烯取代喹啉衍生物在制备抗耐药菌药物中的应用。- 201810463223.X,授权

[7] 卢宇靖 蔡森源 郭晓路 黄宝华 张焜。酚酞半抗原、人工抗原及其制备方法。 -201710096284.2,授权;

[8] 卢宇靖 蔡森源 郭晓路 黄宝华 张焜。氨基他达那非半抗原、人工抗原及其制备方法。 - 201710096282.3,授权;

[9] 卢宇靖 郭晓路 张焜 黄宝华 郑园园。一种荧光探针及其制备方法。 -201710086072.6,授权;

[10] 卢宇靖 郑园园 孙宁 张焜 黄宝华。噻唑橙苯乙烯衍生物及其制备方法和在制备抗耐药菌药物中的应用。- 201610514625.9,授权;

[11] 卢宇靖 邓强 张焜 方岩雄 胡冬萍 王郑亚 杜志云 黄宝华。一种RNA荧光探针及其制备方法和应用。- 201510213542.1,授权;

[12] 卢宇靖 邓强 张焜 方岩雄 胡冬萍 王郑亚 杜志云 黄宝华 陈俊禧 黄飞鸿。噻唑橙苯乙烯类化合物作为G-四链体核酸荧光探针。 - 201510213543.6,授权;

[13] 卢宇靖 胡冬萍 张焜 方岩雄 邓强 王郑亚 杜志云 黄宝华。多苯乙烯取代吡啶化合物作为G-四链体核酸荧光探针。- 201510213744.6,授权;

[14] 卢宇靖 张焜 黄宝华 杜志云 庄子翀 雷琳 付成杰 胡冬萍 邓强 王郑亚。常山碱衍生物及其在制备抗耐药菌药物中的应用。- 201410168506.3;103980251B,授权;

[15] 卢宇靖 张焜 A•H•康尼 郑希 张瑞瑞 杜志云 张瑞芳 付成杰 周代营 王华倩 方岩雄赵肃清 黄宝华。一种苯胺基取代甲基苯并呋喃喹啉衍生物及其制备方法和应用。- 201210117361.5,授权。


部分申请的发明专利:

[1] 卢宇靖 郑伯鑫 龙威 陈翠翠 李莹 蔡森源 黄玄贺 佘梦婷。一种化合物的应用。-201910823714.5;

[2] 佘梦婷 卢宇靖 黄玄贺 郑伯鑫 龙威 李莹 陈翠翠。一种喹啉芳香乙烯类衍生物及在制备荧光染料和荧光探针中的应用。- 201910798217.4;

[3] 佘梦婷 卢宇靖 蔡森源 帅文乐 黄玄贺 李莹 陈翠翠。一种噻唑橙苄基类季铵盐衍生物及其制备方法和应用。- 201910742671.8;

[4] 黄玄贺 卢宇靖 蔡森源 李莹 龙威 张焜 黄宝华。一种曲美他嗪半抗原、人工抗原及其制备方法和应用。- 201810632217.2;

[5] 黄玄贺 卢宇靖 蔡森源 李莹 龙威 黄宝华 张焜。西地那非半抗原、人工抗原及其制备方法。- 201810246409.X;

[6] 蔡森源 卢宇靖 黄玄贺 李莹 龙威 黄宝华 张焜。西地那非半抗原、人工抗原及其制备方法。 - 201810247752.6。


代表性科研项目:

1、广东省基础与应用基础研究基金委员会, 面上项目, 2024A1515010769, 线粒体G4配体苯并吲哚衍生物的设计合成及其诱导 "冷"肿瘤"热"转换的抗癌效应与机制研究, 2024-01 至 2026-12, 15万元, 在研, 主持

2、广东省科学技术厅“海外名师”项目:分子探针与精准医疗(GK4220026 )[10万,2022.09-2023.12,主持]

3、智慧医疗创新技术中心揭榜制专项:靶向癌基因 G4 的荧光多模成像技术及内窥镜的开发(26330320901)[50万,2022.11-2023.12,主持]

4、广东省基础与应用基础研究基金-区域联合基金(地区培育项目):轻量化人工智能算法辅助精准除颤的应用研究(2022A1515140033)[30万,2022.10-2025.09,合作单位主持]

5、国家自然科学基金面上基金:耐药菌特异性蛋白FtsZ新型抑制剂的发现与作用机理研究(81473082) [65万,2015.01-2018.12,主持];

6、广东省农业厅农业科技创新项目:柑橘功能因子的生物酶法制备及其产业化应用关键技术研发(2018LM2175)[50万,2019.01.01-2020.12.31,主持];

7、广东省自然科学基金:耐药菌分裂蛋白FtsZ抑制剂的设计合成及其抗菌作用与机理研究 (2017A030313078)[10万,2017-05-01 至 2020-05-01,主持];

8、国家自然科学基金青年基金:新型荧光探针MQ-TO 细胞内实时示踪G-四链体DNA行为的研究(21102021)[25万,2012.01-2014.12,主持];

9、广州市产学研协调创新重大专项:基于免疫胶体金技术的非法添加快筛试剂盒研发[100万,2015-2017,合作单位主持]。

10、广东省自然科学基金博士启动基金:噻唑取代吲哚喹啉荧光示踪细胞内核酸G-四链体结构的研究(S2011040004201)[3万,2011.10-2013.10,主持]

11、广东工业大学“培英育才”(科研类)人才项目:基于天然产物开发抗肿瘤药物的基础研究[40万,2012.5-2016.5,主持]

12、广东省科技计划攻关项目:抗球虫药常山酮全合成新工艺的开发研究(No.2012B020306007) [8万,2012-2014,排名第二]

13、广东省省级科技计划项目:柚类黄酮高值化利用开发天然甜味剂及其质量认证标准体系的建立(2016A020209009)[30万,2016.07-2018.12,排名第二]

14、广东省科技厅“扬帆计划”创新创业团队项目:金柚高值化利用创业团队,(510093637143)[300万,2016.04-2019.12,骨干成员]


教学活动:

主要从事制药工程相关的专业课程,如《专业导论》、《专业英语》、《药物合成反应》、《专业实验》等课程的理论教学及实践教学。


我的团队:

本团队隶属于“广工大绿色化学与天然药物研究所”以及“广东省药食同源植物资源开发与利用工程中心”;校内主要合作者包括:张焜教授、黄宝华教授、金富军副教授、陈修财副教授、方志远副教授、何燕副教授、汤亚东副教授、刘旭杰副教授、王华倩副教授等。

地址:广州市番禺区广州大学城外环西路100号广东工业大学行政楼325 邮编:510006

电话:020-39322722 邮箱:yzb@gdut.edu.cn粤ICP备05008833号

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